GcMAF Enhances Fc-receptor Mediated Rosette Formation but Hardly Affects Superoxide Production in Human Monocytes.
GcMAF has been reported as a potent macrophage activating factor derived from serum Gc protein (Gc globulin). We compared the effects of GcMAF with those of IFN-.GAMMA. on the morphology, superoxide production and Fc-receptor mediated rosette formation of human monocytes from peripheral blood.
As a result, monocytes stimulated by GcMAF showed hardly any effects on morphological changes and superoxide production, but enhanced Fc-receptor mediated rosette formation. On the other hand, treatment of monocytes with IFN-.GAMMA. increased adherent cells and induced morphological changes.
Therefore, superoxide production per cell protein of adherent monocytes treatment with IFN-.GAMMA. was significantly decreased, and slight effects were observed on Fc-receptor mediated rosette formation. These results indicate that effects of GcMAF on human monocytes were different from those of IFN-.GAMMA.
|Title;GcMAF Enhances Fc-receptor Mediated Rosette Formation but Hardly Affects Superoxide Production in Human Monocytes.|
|Author;OYAMA YUJIRO(Hayashibaraseibutsukagakuken Kankoshikisoken) NAKAGAWA YOSHINORI(Hayashibaraseibutsukagakuken Kankoshikisoken) HORI HITOSHI(Univ. of Tokushima, Fac. of Eng.) NAMBA MASAYOSHI(Okayamadai I Saibouseibutsugaku)|
|Journal Title;Biotherapy (Tokyo)|
|Figure&Table&Reference;FIG.2, TBL.2, REF.14|